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TargetRenin
LigandBDBM50282598
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195791 (CHEMBL801712)
IC50 4±n/a nM
Citation Smith, SAAl-Barazanji, KABuckingham, RECassidy, FColdwell, MCFinney, FJHadley, MSHam, PLawrence, SANash, DJTingley, EJWatson, JM The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration. Bioorg Med Chem Lett4:1291-1296 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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  Blast E-value cutoff:
BDBM50282598
n/a
NameBDBM50282598
Synonyms:(3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{(S)-2-[3-(2-oxo-2,3-dihydro-pyrido[3,4-b][1,4]thiazin-1-yl)-propionylamino]-3-phenyl-propionylamino}-pentanoylamino)-pentanoic acid (3-imidazol-1-yl-propyl)-amide | CHEMBL284569
TypeSmall organic molecule
Emp. Form.C42H58N8O6S
Mol. Mass.803.025
SMILESCC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1C(=O)CSc2cnccc12)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NCCCn1ccnc1
Structure
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