| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50282610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195791 (CHEMBL801712) |
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| IC50 | 38±n/a nM |
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| Citation |  Smith, SA; Al-Barazanji, KA; Buckingham, RE; Cassidy, F; Coldwell, MC; Finney, FJ; Hadley, MS; Ham, P; Lawrence, SA; Nash, DJ; Tingley, EJ; Watson, JM The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration. Bioorg Med Chem Lett4:1291-1296 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50282610 |
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| n/a |
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| Name | BDBM50282610 |
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| Synonyms: | (3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{(S)-2-[2-(3-oxo-2,3-dihydro-pyrido[4,3-b][1,4]thiazin-4-yl)-acetylamino]-3-phenyl-propionylamino}-pentanoylamino)-pentanoic acid (3-imidazol-1-yl-propyl)-amide | CHEMBL436543 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H56N8O6S |
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| Mol. Mass. | 788.998 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN1C(=O)CSc2ccncc12)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NCCCn1ccnc1 |
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| Structure | 
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