| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil elastase |
|---|
| Ligand | BDBM50282865 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_64002 |
|---|
| Ki | 1.8±n/a nM |
|---|
| Citation |  Hlasta, DJ; Bell, MR; Boaz, NW; Court, JJ; Desai, RC; Franke, CA; Mura, AJ; Subramanyam, C; Dunlap, RP A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase Bioorg Med Chem Lett4:1801-1806 (1994) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil elastase |
|---|
| Name: | Neutrophil elastase |
|---|
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28532.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08246 |
|---|
| Residue: | 267 |
|---|
| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
|---|
| BDBM50282865 |
|---|
| n/a |
|---|
| Name | BDBM50282865 |
|---|
| Synonyms: | 2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL299784 | PD120339 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H6ClNO3S |
|---|
| Mol. Mass. | 231.656 |
|---|
| SMILES | ClCN1C(=O)c2ccccc2S1(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
