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Reaction Details
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TargetLeukocyte elastase
LigandBDBM50282865
Substrate/Competitorn/a
Meas. Tech.ChEBML_64002
Ki 1.8±n/a nM
Citation Hlasta DJBell MRBoaz NWCourt JJDesai RCFranke CAMura AJSubramanyam CDunlap RP A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase Bioorg Med Chem Lett 4:1801-1806 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50282865
n/a
NameBDBM50282865
Synonyms:2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL299784
TypeSmall organic molecule
Emp. Form.C8H6ClNO3S
Mol. Mass.231.656
SMILESClCN1C(=O)c2ccccc2S1(=O)=O
Structure
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