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TargetNeutrophil elastase
LigandBDBM50282873
Substrate/Competitorn/a
Meas. Tech.ChEBML_64002
Ki 0.600000±n/a nM
Citation Hlasta, DJBell, MRBoaz, NWCourt, JJDesai, RCFranke, CAMura, AJSubramanyam, CDunlap, RP A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase Bioorg Med Chem Lett4:1801-1806 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50282873
n/a
NameBDBM50282873
Synonyms:4-sec-Butyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL50830
TypeSmall organic molecule
Emp. Form.C19H19N5O3S2
Mol. Mass.429.516
SMILESCCC(C)c1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O
Structure
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