| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50061054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_86531 |
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| Ki | 0.810000±n/a nM |
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| Citation |  Bernstein, PR; Kosmider, BJ; Vacek, EP; Veale, CA; Gomes, BC Examination of peptidic α′,β-diamino-α,α-difluoroketones as inhibitors of human leukocyte elastase Bioorg Med Chem Lett4:2175-2178 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50061054 |
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| n/a |
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| Name | BDBM50061054 |
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| Synonyms: | CHEMBL110125 | CHEMBL66128 | {(S)-1-[(S)-2-((S)-4-Amino-3,3-difluoro-1-isopropyl-2-oxo-butylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid phenyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34F2N4O5 |
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| Mol. Mass. | 496.5474 |
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| SMILES | CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)CN |
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| Structure | 
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