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TargetCaspase-1
LigandBDBM50283339
Substrate/Competitorn/a
Meas. Tech.ChEBML_91005
Ki>20000±n/a nM
Citation Mullican MDLauffer DJGillespie RJMatharu SSKay DPorritt GMEvans PLGolec JMMurcko MALuong YPRaybuck SALivingston DJ The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice. Bioorg Med Chem Lett 4:2359-2364 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Caspase-1
Name:Caspase
Synonyms:Caspase 1 | ICE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:Enzyme
Mol. Mass.:45154.13
Organism:Homo sapiens (Human)
Description:P29466
Residue:404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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  Blast E-value cutoff:
BDBM50283339
n/a
NameBDBM50283339
Synonyms:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-N-[(S)-1-((S)-5-oxo-pyrrolidin-3-ylcarbamoyl)-ethyl]-butyramide | CHEMBL80821
TypeSmall organic molecule
Emp. Form.C23H33N5O6
Mol. Mass.475.538
SMILESCC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]1CNC(=O)C1
Structure
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