| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM50283339 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_91005 |
|---|
| Ki | >20000±n/a nM |
|---|
| Citation |  Mullican, MD; Lauffer, DJ; Gillespie, RJ; Matharu, SS; Kay, D; Porritt, GM; Evans, PL; Golec, JM; Murcko, MA; Luong, YP; Raybuck, SA; Livingston, DJ The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice. Bioorg Med Chem Lett4:2359-2364 (1994) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45154.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29466 |
|---|
| Residue: | 404 |
|---|
| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
|---|
| BDBM50283339 |
|---|
| n/a |
|---|
| Name | BDBM50283339 |
|---|
| Synonyms: | (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-N-[(S)-1-((S)-5-oxo-pyrrolidin-3-ylcarbamoyl)-ethyl]-butyramide | CHEMBL80821 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H33N5O6 |
|---|
| Mol. Mass. | 475.538 |
|---|
| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]1CNC(=O)C1 |
|---|
| Structure | 
|
|---|
Search and Browse
