Reaction Details |
| Report a problem with these data |
Target | Type-2 angiotensin II receptor |
---|
Ligand | BDBM50030719 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_36766 |
---|
IC50 | 1±n/a nM |
---|
Citation | Chang, LL; Ashton, WT; Flanagan, KL; Rivero, RA; Chen, TB; O'Malley, SS; Zingaro, GJ; Kivlighn, SD; Siegl, PK; Lotti, VJ; Chang, RS; Greenlee, WJ Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes Bioorg Med Chem Lett4:2787-2792 (1994) Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Type-2 angiotensin II receptor |
---|
Name: | Type-2 angiotensin II receptor |
Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41346.62 |
Organism: | RAT |
Description: | Angiotensin II AT2 0 0::P35351 |
Residue: | 363 |
Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
|
|
|
BDBM50030719 |
---|
n/a |
---|
Name | BDBM50030719 |
Synonyms: | 4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-2-[5-(propionylamino)-2-(trifluoromethyl)phenyl]-3H-1,2,4-trizol-3-one | CHEMBL276674 | N-{3-[3-Butyl-5-oxo-4-(2'-(N-t-butyloxycarbonyl)-Sulfanamido-biphenyl-4-ylmethyl)-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-propionamide | N-{3-[3-Butyl-5-oxo-4-(2'-(tert-butyloxycarbonyl)sulfamoyl-biphenyl-4-ylmethyl)-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-propionamide |
Type | Small organic molecule |
Emp. Form. | C34H38F3N5O6S |
Mol. Mass. | 701.756 |
SMILES | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C |
Structure |
|