Reaction Details |
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Target | Type-2 angiotensin II receptor |
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Ligand | BDBM50030732 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_36650 (CHEMBL649910) |
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IC50 | 12±n/a nM |
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Citation | Chang, LL; Ashton, WT; Flanagan, KL; Rivero, RA; Chen, TB; O'Malley, SS; Zingaro, GJ; Kivlighn, SD; Siegl, PK; Lotti, VJ; Chang, RS; Greenlee, WJ Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes Bioorg Med Chem Lett4:2787-2792 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-2 angiotensin II receptor |
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Name: | Type-2 angiotensin II receptor |
Synonyms: | AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41201.61 |
Organism: | Homo sapiens (Human) |
Description: | Angiotensin II, central 0 0::P50052 |
Residue: | 363 |
Sequence: | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
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BDBM50030732 |
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n/a |
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Name | BDBM50030732 |
Synonyms: | CHEMBL323506 | N-{3-[3-Butyl-4-(3-fluoro-2'(tert-butoxycarbonyl) sulfamoyl-5'-propyl-biphenyl-4-ylmethyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-chloro-phenyl}-acetamide | N-{3-[3-Butyl-4-(3-fluoro-5'-propyl-2'-(N-t-butyloxycarbonyl)-Sulfanamido-biphenyl-4-ylmethyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-chloro-phenyl}-acetamide |
Type | Small organic molecule |
Emp. Form. | C35H41ClFN5O6S |
Mol. Mass. | 714.246 |
SMILES | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1cc(CCC)ccc1S(=O)(=O)NC(=O)OC(C)(C)C |
Structure |
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