| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50283783 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101742 |
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| IC50 | 150±n/a nM |
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| Citation |  Hunter, DJ; Bird, J; Cassidy, F; De Mello, RC; Harper, GP; Karran, EH; Markwell, RE; Miles-Williams, AJ; Ward, RW Aminophosphonic acid containing inhibitors of human collagenase: modification of the P1 residue Bioorg Med Chem Lett4:2833-2836 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50283783 |
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| n/a |
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| Name | BDBM50283783 |
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| Synonyms: | CHEMBL330729 | {(S)-3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-1-[(S)-3-methyl-1-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-butylamino]-propyl}-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C31H37N4O7P |
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| Mol. Mass. | 608.6218 |
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| SMILES | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cccc3cccc(C1=O)c23)P(O)(O)=O |
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| Structure | 
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