Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM383 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_79807 (CHEMBL696067) |
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IC50 | 0.06±n/a nM |
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Citation | Vacca, JP; Fitzgerald, PM; Holloway, MK; Hungate, RW; Starbuck, KE; Chen, LJ; Darke, PL; Anderson, PS; Huff, JR Conformationally constrained HIV-1 protease inhibitors Bioorg Med Chem Lett4:499-504 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM383 |
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n/a |
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Name | BDBM383 |
Synonyms: | (3S)-oxolan-3-yl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}-1-phenylpentan-2-yl]carbamate | Urethane deriv. 2 |
Type | Small organic molecule |
Emp. Form. | C33H38N2O6 |
Mol. Mass. | 558.6646 |
SMILES | O[C@@H](C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1 |r| |
Structure |
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