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TargetPeptidyl-prolyl cis-trans isomerase FKBP1A
LigandBDBM50284196
Substrate/Competitorn/a
Meas. Tech.ChEBML_66282
EC50 15±n/a nM
Citation Goulet, MTHodkey, DWStaruch, MJDumont, FJLin, SHung, SHSiekierka, JJWyvratt, MJ Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin) Bioorg Med Chem Lett4:927-930 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP1A
Name:Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:Isomerase
Mol. Mass.:11953.09
Organism:Homo sapiens (Human)
Description:P62942
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50284196
n/a
NameBDBM50284196
Synonyms:C32-O-cinnamyl ether analogue of L-683590 | CHEMBL174029
TypeSmall organic molecule
Emp. Form.C46H73NO12
Mol. Mass.832.0713
SMILESCC[C@@H]1\C=C(C)\C[C@H](C)C[C@H](OC)[C@H]2OC(O)([C@@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(\C)=C\[C@@H]1CC[C@@H](OC(C)C=C)[C@H](O)C1 |c:3|
Structure
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