| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50017896 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_209938 (CHEMBL811918) |
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| IC50 | 10000±n/a nM |
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| Citation |  Hamanaka, N; Takahashi, K; Nagao, Y; Torisu, K; Shigeoka, S; Hamada, S; Kato, H; Tokumoto, H; Kondo, K Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. I Bioorg Med Chem Lett5:1087-1090 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50017896 |
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| n/a |
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| Name | BDBM50017896 |
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| Synonyms: | (E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid | 3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid | CHEMBL11662 | CHEMBL542549 | Ozagrel | cid_5282440 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N2O2 |
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| Mol. Mass. | 228.2466 |
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| SMILES | OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1 |
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| Structure | 
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