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Reaction Details
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TargetCysteinyl leukotriene receptor 1
LigandBDBM50070921
Substrate/Competitorn/a
Meas. Tech.ChEBML_99992
Ki 24000±n/a nM
Citation Andrews, EGAntognoli, GWBreslow, RCarta, MPCarty, TJChambers, RJCheng, JBCohan, VLCollins, JLDamon, DBDelehunt, JEggler, JFEskra, JDFreiert, KWHada, WAMarfat, AMasamune, HMelvin, LSMularski, CJNaclerio, BA Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists Bioorg Med Chem Lett5:1365-1370 (1995)    Article
More Info.:Get all data from this article,  Assay Method
 
Cysteinyl leukotriene receptor 1
Name:Cysteinyl leukotriene receptor 1
Synonyms:CLTR1_CAVPO | CYSLTR1
Type:Enzyme Catalytic Domain
Mol. Mass.:39007.58
Organism:GUINEA PIG
Description:Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50070921
n/a
NameBDBM50070921
Synonyms:3-[(3R,4R)-6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy-chroman-3-ylmethyl]-benzoic acid | 3-[6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy-chroman-3-ylmethyl]-benzoic acid | CHEMBL442150
TypeSmall organic molecule
Emp. Form.C25H20FNO5S
Mol. Mass.465.493
SMILESO[C@@H]1[C@H](Cc2cccc(c2)C(O)=O)COc2ccc(OCc3nc4cc(F)ccc4s3)cc12
Structure
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