| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50284752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101765 |
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| Ki | 432±n/a nM |
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| Citation |  Castelhano, AL; Billedeau, R; Dewdney, N; Donnelly, S; Horne, S; Kurz, LJ; Liak, TJ; Martin, R; Uppington, R; Yuan, Z; Krantz, A Novel indolactam-based inhibitors of matrix metalloproteinases Bioorg Med Chem Lett5:1415-1420 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50284752 |
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| n/a |
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| Name | BDBM50284752 |
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| Synonyms: | CHEMBL31164 | {(S)-2-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-methyl-pentyl}-(quinolin-2-ylsulfanylmethyl)-phosphinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C34H45N4O4PS |
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| Mol. Mass. | 636.784 |
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| SMILES | CCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CP(O)(=O)CSc1ccc2ccccc2n1 |
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| Structure | 
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