| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50284842 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54063 |
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| Ki | 30±n/a nM |
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| Citation |  Batt, DG; Copeland, RA; Dowling, RL; Gardner, TL; Jones, EA; Orwat, MJ; Pinto, DJ; Pitts, WJ; Magolda, RL; Jaffee, BD Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivatives Bioorg Med Chem Lett5:1549-1554 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM50284842 |
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| n/a |
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| Name | BDBM50284842 |
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| Synonyms: | 2-Biphenyl-4-yl-3-ethyl-6-fluoro-quinoline-4-carboxylic acid | CHEMBL36047 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18FNO2 |
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| Mol. Mass. | 371.4036 |
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| SMILES | CCc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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