| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C eta type |
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| Ligand | BDBM50285087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_161133 |
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| IC50 | 3±n/a nM |
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| Citation |  Jr., GE; Defauw, JM; Lai, YS; Crane, HM; Hall, SE; Buben, JA; Hu, H; Gosnell, PA Novel PKC inhibitory analogs of balanol with replacement of the ester functionality Bioorg Med Chem Lett5:2015-2020 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C eta type |
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| Name: | Protein kinase C eta type |
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| Synonyms: | KPCL_HUMAN | PKC-L | PKCL | PRKCH | PRKCL | Protein Kinase C, eta | Protein kinase C, PKC; classical/novel | nPKC-eta |
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| Type: | Enzyme |
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| Mol. Mass.: | 77844.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 683 |
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| Sequence: | MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
GHLPMINQDEFRNFSYVSPELQP
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| BDBM50285087 |
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| n/a |
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| Name | BDBM50285087 |
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| Synonyms: | (R)-2-{2,6-Dihydroxy-4-[(3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-ylcarbamoyl]-benzoyl}-3-hydroxy-benzoic acid | CHEMBL59677 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23N3O9 |
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| Mol. Mass. | 521.4755 |
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| SMILES | OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)N[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |
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| Structure | 
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