Ki Summary

Reaction Details

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Target

Beta-lactamase 1

Ligand

BDBM50021954

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_40228

IC50

25000±n/a nM

Citation

Danelon, GO; Mata, EG; Mascaretti, OA; Girardini, J; Marro, M; Roveri, OA Synthesis and β-lactamase inhibitory evaluation of novel 6α-halo-2β-chloromethyl-2α-methylpenam-3α-carboxylic acids and their sulfones and 6α-halo-2β-mercaptobenzothiazolylmethyl-2α-methylpenam-3α-carboxylic acids Bioorg Med Chem Lett5:2037-2040 (1995) Article

More Info.:

Get all data from this article, Assay Method

Beta-lactamase 1

Name:

Beta-lactamase 1

Synonyms:

BLAC_BACCE | blaY

Type:

PROTEIN

Mol. Mass.:

33326.66

Organism:

Bacillus cereus

Description:

ChEMBL_40230

Residue:

306

Sequence:

MILKNKRMLKIGICVGILGLSITSLEAFTGESLQVEAKEKTGQVKHKNQATHKEFSQLEK
KFDARLGVYAIDTGTNQTISYRPNERFAFASTYKALAAGVLLQQNSIDSLNEVITYTKED
LVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGGPKGYEKALRHMGDRITM
SNRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEKRKILTEWMKGNATGDKLI
RAGIPTDWVVGDKSGAGSYGTRNDIAVVWPPNSAPIIVLISSKDEKEAIYNDQLIAEATK
VIVKGS

BDBM50021954

n/a

Name

BDBM50021954

Synonyms:

(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam) | CHEMBL403 | CP-45,899 | SULBACTAM | UNASYN | US20230322715, Compound ALK-09 | US9120808, Sulbactam sodium salt

Type

Small organic molecule

Emp. Form.

C8H11NO5S

Mol. Mass.

233.242

SMILES

CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O |r|

Structure