| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
|---|
| Ligand | BDBM50285230 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_208256 |
|---|
| IC50 | 170±n/a nM |
|---|
| Citation |  Peel, MR; Milstead, MW; Sternbach, DD; Besterman, JM; Leitner, P; Morton, B; Wall, ME; Wani, MC Novel A-ring modified camptothecins as topoisomerase I inhibitors Bioorg Med Chem Lett5:2129-2132 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 1 |
|---|
| Name: | DNA topoisomerase 1 |
|---|
| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90771.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11387 |
|---|
| Residue: | 765 |
|---|
| Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
|
|
|
|---|
| BDBM50285230 |
|---|
| n/a |
|---|
| Name | BDBM50285230 |
|---|
| Synonyms: | (S)-9-Amino-4-ethyl-4,8-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | CHEMBL67115 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17N3O5 |
|---|
| Mol. Mass. | 379.3661 |
|---|
| SMILES | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(O)c(N)cc4cc3Cn1c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
