| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50285284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_86286 (CHEMBL698901) |
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| Ki | 0.08±n/a nM |
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| Citation |  Desai, RC; Dunlap, RP; Farrell, RP; Ferguson, E; Franke, CA; Gordon, R; Hlasta, DJ; Talomie, TG Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastase Bioorg Med Chem Lett5:105-109 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50285284 |
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| n/a |
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| Name | BDBM50285284 |
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| Synonyms: | 2,6-Dichloro-benzoic acid 4,6-diethoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL11874 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17Cl2NO7S |
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| Mol. Mass. | 474.312 |
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| SMILES | CCOc1cc2c(C(=O)N(COC(=O)c3c(Cl)cccc3Cl)S2(=O)=O)c(OCC)c1 |
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| Structure | 
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