| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM50064106 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_144606 |
|---|
| IC50 | 930±n/a nM |
|---|
| Citation |  Lombaer, SD; Blanchard, L; Berry, C; Ghai, RD; Trapani, AJ Non-peptidic inhibitors of neutral endopeptidase 24.11 2. Design and pharmacology of orally active phosphonate prodrugs Bioorg Med Chem Lett5:151-154 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 85789.59 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07861 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
|
|
|
|---|
| BDBM50064106 |
|---|
| n/a |
|---|
| Name | BDBM50064106 |
|---|
| Synonyms: | CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid | {[(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid | {[(S)-2-Biphenyl-4-yl-1-(2H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid | {[2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-methyl}-phosphonic acid(CGS 26303) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H18N5O3P |
|---|
| Mol. Mass. | 359.3196 |
|---|
| SMILES | OP(O)(=O)CN[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
