| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
|---|
| Ligand | BDBM50450347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_28360 |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Wilde, RG; Billheimer, JT Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing two heterocyclic head groups Bioorg Med Chem Lett5:173-6 (1995) |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sterol O-acyltransferase 1 |
|---|
| Name: | Sterol O-acyltransferase 1 |
|---|
| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 64165.56 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_28796 |
|---|
| Residue: | 545 |
|---|
| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
|
|
|
|---|
| BDBM50450347 |
|---|
| n/a |
|---|
| Name | BDBM50450347 |
|---|
| Synonyms: | CHEMBL431940 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C51H56F2N8OS2 |
|---|
| Mol. Mass. | 899.17 |
|---|
| SMILES | CN(C)c1ccc(cc1)-c1nc(SCCCCCN(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)C(=O)Nc2ccc(F)cc2F)[nH]c1-c1ccc(cc1)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
