| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-1 |
|---|
| Ligand | BDBM50241370 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_101950 |
|---|
| Ki | 230±n/a nM |
|---|
| Citation |  Sahoo, SP; Caldwell, CG; Chapman, KT; Durette, PL; Esser, CK; Kopka, IE; Polo, SA; Sperow, KM; Niedzwiecki, LM; Izquierdo-Martin, M; Chang, BC; Harrison, RK; Stein, RL; MacCoss, M; Hagmann, WK Inhibition of matrix metalloproteinases by N-carboxyalkyl dipeptides: Enhanced potency and selectivity with substituted P1′ homophenylalanines Bioorg Med Chem Lett5:2441-2446 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-1 |
|---|
| Name: | Stromelysin-1 |
|---|
| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53973.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08254 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
|
|
|
|---|
| BDBM50241370 |
|---|
| n/a |
|---|
| Name | BDBM50241370 |
|---|
| Synonyms: | (R)-2-[(S)-1-((S)-4-guanidino-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-propionic acid | CHEMBL251481 | L-702842 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H34N6O4 |
|---|
| Mol. Mass. | 482.5753 |
|---|
| SMILES | [#6]-[#6@@H](-[#7]-[#6@@H](-[#6]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c1ccccc1)-[#6](-[#8])=O |
|---|
| Structure | 
|
|---|
Search and Browse
