Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50285701 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_79978 (CHEMBL874137) |
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Ki | 0.070±n/a nM |
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Citation | Randad, RS; Lubkowska, L; Bujacz, A; Naik, RH; Gulnik, SV; Yu, B; Silva, A; Munshi, S; Lynch, TM; Clanton, DJ; Bhat, TN; Erickson, JW Structure-based design of achiral anthranilamides as P2/P2′ surrogates for symmetry-based HIV protease inhibitors: design, synthesis, X-ray structure, enzyme inhibition and antiviral activity Bioorg Med Chem Lett5:2557-2562 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50285701 |
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n/a |
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Name | BDBM50285701 |
Synonyms: | Anthranilamide derivative | CHEMBL313767 |
Type | Small organic molecule |
Emp. Form. | C46H44N6O7 |
Mol. Mass. | 792.8776 |
SMILES | O[C@@H](C[C@H](Cc1ccccc1)NC(=O)c1ccccc1NC(=O)OCc1ccccn1)[C@H](Cc1ccccc1)NC(=O)c1ccccc1NC(=O)OCc1ccccn1 |
Structure |
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