Reaction Details |
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Target | Platelet-activating factor receptor |
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Ligand | BDBM50286203 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_164930 |
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IC50 | 3±n/a nM |
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Citation | Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J Enantiodifferentiation of dihydropyridine PAF antagonists Bioorg Med Chem Lett5:3085-3090 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor receptor |
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Name: | Platelet-activating factor receptor |
Synonyms: | PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39219.60 |
Organism: | Homo sapiens (Human) |
Description: | PAF Platelet activating factor PTAFR HUMAN::P25105 |
Residue: | 342 |
Sequence: | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
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BDBM50286203 |
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n/a |
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Name | BDBM50286203 |
Synonyms: | 4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-benzoimidazol-1-yl)-ethoxymethyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester | CHEMBL104290 |
Type | Small organic molecule |
Emp. Form. | C32H32ClN5O4 |
Mol. Mass. | 586.081 |
SMILES | CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23| |
Structure |
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