Reaction Details |
| Report a problem with these data |
Target | Sterol O-acyltransferase 1 |
---|
Ligand | BDBM50450398 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_28484 |
---|
IC50 | 52±n/a nM |
---|
Citation | O'Brien, PM; Sliskovic, DR; Bernabei, A; Hurley, T; Anderson, MK; Bousley, RF; Krause, BK; Stanfield, RL Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 13. Design, synthesis and biological evaluation of tetrazole anilides as potent inhibitors of ACAT in vitro and hypocholesterolemic agents in vivo Bioorg Med Chem Lett5:295-300 (1995) |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sterol O-acyltransferase 1 |
---|
Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
Type: | PROTEIN |
Mol. Mass.: | 64165.56 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_28796 |
Residue: | 545 |
Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
|
|
|
BDBM50450398 |
---|
n/a |
---|
Name | BDBM50450398 |
Synonyms: | CHEMBL100448 |
Type | Small organic molecule |
Emp. Form. | C30H43N5O4 |
Mol. Mass. | 537.6935 |
SMILES | CCCCCCCCCCCCn1nnnc1C(C(=O)Nc1c(OC)cc(OC)cc1OC)c1ccccc1 |
Structure |
|