Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50286326 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_86695 |
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Ki | 0.030000±n/a nM |
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Citation | Hlasta, DJ; Bell, MR; Court, JJ; Cundy, KC; Desai, RC; Ferguson, EW; Gordon, RJ; Kumar, V; Maycock, AL; Subramanyam, C; Dunlap, RP; Eiff, SL; Franke, CA; Mura, AJ; Rowlands, AG The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase Bioorg Med Chem Lett5:331-336 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50286326 |
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n/a |
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Name | BDBM50286326 |
Synonyms: | 2,6-Dichloro-benzoic acid 6-fluoro-4-isopropyl-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL325155 |
Type | Small organic molecule |
Emp. Form. | C18H14Cl2FNO5S |
Mol. Mass. | 446.277 |
SMILES | CC(C)c1cc(F)cc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O |
Structure |
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