| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50029699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_86698 (CHEMBL694289) |
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| KON | 522000 M-1s-1 |
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| Citation |  Hlasta, DJ; Bell, MR; Court, JJ; Cundy, KC; Desai, RC; Ferguson, EW; Gordon, RJ; Kumar, V; Maycock, AL; Subramanyam, C; Dunlap, RP; Eiff, SL; Franke, CA; Mura, AJ; Rowlands, AG The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase Bioorg Med Chem Lett5:331-336 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50029699 |
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| n/a |
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| Name | BDBM50029699 |
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| Synonyms: | 2,6-Dichloro-benzoic acid 4-isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL115827 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17Cl2NO6S |
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| Mol. Mass. | 458.312 |
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| SMILES | COc1cc2c(C(=O)N(COC(=O)c3c(Cl)cccc3Cl)S2(=O)=O)c(c1)C(C)C |
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| Structure | 
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