| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50286334 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49511 |
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| Ki | 2±n/a nM |
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| Citation |  Singh, J; Conzentino, P; Cundy, K; Gainor, JA; Gilliam, CL; Gordon, TD; Johnson, JA; Morgan, BA; Schneider, ED; Wahl, RC; Whipple, DA Relationship between structure and bioavailability in a series of hydroxamate based metalloprotease inhibitors Bioorg Med Chem Lett5:337-342 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50286334 |
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| n/a |
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| Name | BDBM50286334 |
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| Synonyms: | (R)-N*4*-Hydroxy-N*1*-{(S)-2-(1H-indol-3-yl)-1-[5-(4-methoxy-phenyl)-5-oxo-pentylcarbamoyl]-ethyl}-2-isobutyl-succinamide | CHEMBL113894 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40N4O6 |
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| Mol. Mass. | 564.6725 |
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| SMILES | COc1ccc(cc1)C(=O)CCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO |
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| Structure | 
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