Ki Summary

Reaction Details

Report a problem with these data

Target

Matrix metalloproteinase-1 (MMP1)

Ligand

BDBM50089194

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_101763

300±n/a nM

Citation

Wahl RC; Pulvino TA; Mathiowetz AM; Ghose AK; Johnson JS; Delecki D; Cook ER; Gainor JA; Gowravaram MR; Tomczuk BE Hydroxamate inhibitors of human gelatinase B (92 kDa) Bioorg Med Chem Lett 5:349-352 (1995) Article

More Info.:

Get all data from this article, Assay Method

Matrix metalloproteinase-1 (MMP1)

Name:

Matrix metalloproteinase (1 and 13)

Synonyms:

Fibroblast collagenase | Interstitial collagenase | MMP1 | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)

Type:

Enzyme

Mol. Mass.:

54010.26

Organism:

Homo sapiens (Human)

Description:

Residue:

469

Sequence:

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

BDBM50089194

n/a

Name

BDBM50089194

Synonyms:

(R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide | (R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide | ACTINONIN | CHEMBL308333 | N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide | N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide

Type

Small organic molecule

Emp. Form.

C19H35N3O5

Mol. Mass.

385.4983

SMILES

CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO

Structure