| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain small subunit 1/1 catalytic subunit |
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| Ligand | BDBM50286448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_43696 (CHEMBL653673) |
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| IC50 | >1000±n/a nM |
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| Citation |  Harris, AL; Gregory, JS; Maycock, AL; Graybill, TL; Osifo, IK; Schmidt, SJ; Dolle, RE Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluation of peptide aldehydes, halomethyl ketones and (acyloxy)methyl ketones as inhibitors of the enzyme Bioorg Med Chem Lett5:393-398 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain small subunit 1/1 catalytic subunit |
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| Name: | Calpain small subunit 1/1 catalytic subunit |
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| Synonyms: | Calpain 1 | Calpain 1/small subunit 1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 43671 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Calpain small subunit 1 |
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| Synonyms: | CAPN4 | CAPNS | CAPNS1 | CPNS1_HUMAN | Calpain 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28309.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_12682 |
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| Residue: | 268 |
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| Sequence: | MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR
ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF
RAFKSLDKDGTGQIQVNIQEWLQLTMYS
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| Component 2 |
| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50286448 |
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| n/a |
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| Name | BDBM50286448 |
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| Synonyms: | CHEMBL127663 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-naphthalen-1-yl-ethyl]-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28N2O4 |
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| Mol. Mass. | 480.5543 |
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| SMILES | O=C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1 |
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| Structure | 
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