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TargetCalpain small subunit 1/1 catalytic subunit
LigandBDBM50286452
Substrate/Competitorn/a
Meas. Tech.ChEMBL_43696 (CHEMBL653673)
IC50 25±n/a nM
Citation Harris, ALGregory, JSMaycock, ALGraybill, TLOsifo, IKSchmidt, SJDolle, RE Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluation of peptide aldehydes, halomethyl ketones and (acyloxy)methyl ketones as inhibitors of the enzyme Bioorg Med Chem Lett5:393-398 (1995)    Article
More Info.:Get all data from this article,  Assay Method
 
Calpain small subunit 1/1 catalytic subunit
Name:Calpain small subunit 1/1 catalytic subunit
Synonyms:Calpain 1 | Calpain 1/small subunit 1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 43671
Components:This complex has 2 components.
Component 1
Name:Calpain small subunit 1
Synonyms:CAPN4 | CAPNS | CAPNS1 | CPNS1_HUMAN | Calpain 1
Type:PROTEIN
Mol. Mass.:28309.36
Organism:Homo sapiens (Human)
Description:EBI_12682
Residue:268
Sequence:
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMR
ILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMF
RAFKSLDKDGTGQIQVNIQEWLQLTMYS
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Component 2
Name:Calpain-1 catalytic subunit
Synonyms:CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:Protein
Mol. Mass.:81880.51
Organism:Homo sapiens (Human)
Description:n/a
Residue:714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM50286452
n/a
NameBDBM50286452
Synonyms:CHEMBL340020 | {(S)-1-[(S)-1-(4-Hydroxy-benzyl)-2-oxo-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
TypeSmall organic molecule
Emp. Form.C22H26N2O5
Mol. Mass.398.4522
SMILESCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C=O
Structure
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