| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50286589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_145841 |
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| Ki | 63±n/a nM |
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| Citation |  Napoletano, M; Delia, BD; Fraire, C; Grancini, G; Masotto, C; Ricciardi, S; Zambon, C Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic Bioorg Med Chem Lett5:589-592 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42692.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P34975 |
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| Residue: | 380 |
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| Sequence: | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
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| BDBM50286589 |
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| n/a |
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| Name | BDBM50286589 |
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| Synonyms: | (S)-5-{(S)-2-[Bis-((R)-sec-butyl)-amino]-1-hydroxy-ethyl}-1-(2-chloro-benzyl)-pyrrolidin-2-one | CHEMBL154309 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H33ClN2O2 |
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| Mol. Mass. | 380.952 |
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| SMILES | CC[C@@H](C)N(C[C@H](O)[C@@H]1CCC(=O)N1Cc1ccccc1Cl)[C@H](C)CC |
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| Structure | 
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