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TargetSqualene synthase
LigandBDBM50287113
Substrate/Competitorn/a
Meas. Tech.ChEBML_202100
IC50 90±n/a nM
Citation Lamothe, MPerrin, DBlotières, DLeborgne, MGras, SBonnet, DHill, BTHalazy, S Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine Bioorg Med Chem Lett6:1291-1296 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
Squalene synthase
Name:Squalene synthase
Synonyms:FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:PROTEIN
Mol. Mass.:48109.41
Organism:Rattus norvegicus
Description:ChEMBL_1336736
Residue:416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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  Blast E-value cutoff:
BDBM50287113
n/a
NameBDBM50287113
Synonyms:(S)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phosphonomethyl-tetradeca-4,8,12-trienoylamino)-propionic acid | CHEMBL280737
TypeSmall organic molecule
Emp. Form.C27H40NO6P
Mol. Mass.505.5834
SMILES[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6](-[#6]P([#8])([#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O |w:13.13|
Structure
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