| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50287118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202100 |
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| IC50 | 500±n/a nM |
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| Citation |  Lamothe, M; Perrin, D; Blotières, D; Leborgne, M; Gras, S; Bonnet, D; Hill, BT; Halazy, S Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine Bioorg Med Chem Lett6:1291-1296 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50287118 |
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| n/a |
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| Name | BDBM50287118 |
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| Synonyms: | (R)-3-Phenyl-2-((4E,8E)-5,9,13-trimethyl-2-phosphono-tetradeca-4,8,12-trienoylamino)-propionic acid | CHEMBL285362 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H38NO6P |
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| Mol. Mass. | 491.5568 |
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| SMILES | [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]-[#6]=[#6](-[#6](=O)-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](-[#8])=O)P([#8])([#8])=O |w:14.13| |
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| Structure | 
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