| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50287494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101739 |
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| IC50 | 570±n/a nM |
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| Citation |  Robinson, RP; Ragan, JA; Cronin, BJ; Donahue, KM; Lopresti-Morrow, LL; Mitchell, PG; Reeves, LM; Yocum, SA Inhibitors of MMP-1: an examination of P1′ Cα gem-disubstitution in the succinamide hydroxamate series Bioorg Med Chem Lett6:1719-1724 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50287494 |
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| n/a |
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| Name | BDBM50287494 |
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| Synonyms: | 2-Hydroxycarbamoylmethyl-indan-2-carboxylic acid [(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-amide | CHEMBL433479 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N3O5 |
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| Mol. Mass. | 425.4776 |
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| SMILES | CNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C1(CC(=O)NO)Cc2ccccc2C1 |
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| Structure | 
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