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TargetGTPase HRas
LigandBDBM50287946
Substrate/Competitorn/a
Meas. Tech.ChEBML_143166
IC50 5000±n/a nM
Citation Wolin RWang DKelly JAfonso AJames LKirschmeier PMcPhail AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett 6:195-200 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
GTPase HRas
Name:GTPase HRas
Synonyms:GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:Other Protein Type
Mol. Mass.:21293.37
Organism:Homo sapiens (Human)
Description:P01112
Residue:189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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  Blast E-value cutoff:
BDBM50287946
n/a
NameBDBM50287946
Synonyms:1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-nitro-benzenesulfonyl)-morpholin-2-yl]-4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline | CHEMBL64328
TypeSmall organic molecule
Emp. Form.C29H36ClN5O7SSi
Mol. Mass.662.229
SMILESCOc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Structure
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