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TargetGTPase HRas
LigandBDBM50287947
Substrate/Competitorn/a
Meas. Tech.ChEBML_143166
IC50 16000±n/a nM
Citation Wolin RWang DKelly JAfonso AJames LKirschmeier PMcPhail AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett 6:195-200 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
GTPase HRas
Name:GTPase HRas
Synonyms:GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:Other Protein Type
Mol. Mass.:21293.37
Organism:Homo sapiens (Human)
Description:P01112
Residue:189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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  Blast E-value cutoff:
BDBM50287947
n/a
NameBDBM50287947
Synonyms:(E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-4-(2-nitro-phenylsulfanyl)-morpholin-2-yl]-but-2-enoic acid ethyl ester | CHEMBL299877
TypeSmall organic molecule
Emp. Form.C28H28ClN5O6S
Mol. Mass.598.07
SMILESCCOC(=O)\C=C\C[C@@H]1CN(C[C@@H](O1)n1nc(C)c2c(Cl)c3cc(OC)ccc3nc12)Sc1ccccc1[N+]([O-])=O
Structure
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