| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase HRas |
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| Ligand | BDBM50287949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143166 |
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| IC50 | 14000±n/a nM |
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| Citation |  Wolin, R; Wang, D; Kelly, J; Afonso, A; James, L; Kirschmeier, P; McPhail, AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett6:195-200 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase HRas |
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| Name: | GTPase HRas |
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| Synonyms: | GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 21293.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01112 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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| BDBM50287949 |
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| n/a |
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| Name | BDBM50287949 |
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| Synonyms: | 1-[(2R,6S)-4-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-morpholin-2-yl]-4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline | CHEMBL432297 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37ClN4O5SSi |
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| Mol. Mass. | 617.231 |
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| SMILES | COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccccc1 |
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| Structure | 
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