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TargetGTPase HRas
LigandBDBM50287953
Substrate/Competitorn/a
Meas. Tech.ChEBML_143166
IC50 10500±n/a nM
Citation Wolin, RWang, DKelly, JAfonso, AJames, LKirschmeier, PMcPhail, AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett6:195-200 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
GTPase HRas
Name:GTPase HRas
Synonyms:GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:Other Protein Type
Mol. Mass.:21293.37
Organism:Homo sapiens (Human)
Description:P01112
Residue:189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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  Blast E-value cutoff:
BDBM50287953
n/a
NameBDBM50287953
Synonyms:5-(4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-1-yl)-3,4-di(2-furylcarbonyloxy)-2-(2-furylcarbonyloxymethyl)-(2R,3R,4R,5R)-tetrahydrofuran | CHEMBL304883
TypeSmall organic molecule
Emp. Form.C32H24ClN3O11
Mol. Mass.661.999
SMILESCOc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@@H]1O[C@H](COC(=O)c2ccco2)[C@@H](OC(=O)c2ccco2)[C@H]1OC(=O)c1ccco1
Structure
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