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TargetGTPase HRas
LigandBDBM50287961
Substrate/Competitorn/a
Meas. Tech.ChEBML_143166
IC50 3000±n/a nM
Citation Wolin RWang DKelly JAfonso AJames LKirschmeier PMcPhail AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett 6:195-200 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
GTPase HRas
Name:GTPase HRas
Synonyms:GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:Other Protein Type
Mol. Mass.:21293.37
Organism:Homo sapiens (Human)
Description:P01112
Residue:189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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  Blast E-value cutoff:
BDBM50287961
n/a
NameBDBM50287961
Synonyms:(E)-5-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitro-phenylsulfanyl)-morpholin-2-yl]-pent-3-en-2-one | CHEMBL59515
TypeSmall organic molecule
Emp. Form.C27H26ClN5O5S
Mol. Mass.568.044
SMILESCOc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@H](O1)C=CCC(C)=O)Sc1ccc(cc1)[N+]([O-])=O |w:24.28|
Structure
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