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TargetHuman immunodeficiency virus type 1 reverse transcriptase
LigandBDBM50288070
Substrate/Competitorn/a
Meas. Tech.ChEBML_195047
IC50>100000±n/a nM
Citation Goldring AOGilbert IHMahmood NBalzarini J Lipophilic bioisosteres of nucleoside triphosphates Bioorg Med Chem Lett 6:2411-2416 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 reverse transcriptase
Name:Human immunodeficiency virus type 1 reverse transcriptase
Synonyms:Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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  Blast E-value cutoff:
BDBM50288070
n/a
NameBDBM50288070
Synonyms:(2,4-Dimethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester | CHEMBL312488 | CHEMBL3142414
TypeSmall organic molecule
Emp. Form.C26H44N2O8SSi
Mol. Mass.572.787
SMILESCSCO[C@@]1(C)CO[C@@](C)(CC(=O)OC[C@H]2O[C@H](C[C@@H]2O[Si](C)(C)C(C)(C)C)n2cc(C)c(=O)[nH]c2=O)C1 |r|
Structure
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