| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50024102 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_144431 |
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| Ki | 2.2±n/a nM |
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| Citation |  Danvy, D; Monteil, T; Plaquevent, JC; Duhamel, L; Duhamel, P; Gros, C; Noël, N; Schwartz, JC; Lecomte, JM Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process Bioorg Med Chem Lett6:2437-2440 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
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| Type: | Enzyme |
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| Mol. Mass.: | 85505.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08473 |
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| Residue: | 750 |
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| Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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| BDBM50024102 |
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| n/a |
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| Name | BDBM50024102 |
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| Synonyms: | ((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acid | (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE | (S) (2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acid | 2-[1-(2-Carboxy-2-hydroxy-ethylcarbamoyl)-2-phenyl-ethylamino]-4-phenyl-butyric acid(Thiorphan) | CHEMBL298827 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15NO3S |
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| Mol. Mass. | 253.317 |
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| SMILES | OC(=O)CNC(=O)[C@@H](CS)Cc1ccccc1 |
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| Structure | 
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