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TargetThrombin and coagulation factor X
LigandBDBM50069174
Substrate/Competitorn/a
Meas. Tech.ChEBML_208357
Ki 1.7±n/a nM
Citation Galemmo RAFevig JMCarini DJCacciola JWells BLHillyer GLJr. JBRossi KAStouten PFAlexander RSHilmer RBostrom LAbelman MMLee SLWeber PCKettner CAKnabb RMWexler RR (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors Bioorg Med Chem Lett 6:2913-2918 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
Thrombin and coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | Prothrombin precursor | Thrombin heavy chain | Thrombin light chain
Type:Protein
Mol. Mass.:70029.57
Organism:Homo sapiens (Human)
Description:P00734
Residue:622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50069174
n/a
NameBDBM50069174
Synonyms:Boronate Ester analogue | CHEMBL317682 | N-[(5-Amino-1-dihydroxyboranyl-pentylcarbamoyl)-methyl]-N-methyl-3-phenyl-propionamide
TypeSmall organic molecule
Emp. Form.C17H28BN3O4
Mol. Mass.349.233
SMILESCN(CC(=O)N[C@@H](CCCCN)B(O)O)C(=O)CCc1ccccc1
Structure
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