Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM50288764 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_195891 |
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Ki | 8100±n/a nM |
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Citation | Babine, RE; Bleckman, TM; Littlefield, ES; Parge, HE; Pelletier, LA; Lewis, CT; French, JV; Imbacuan, M; Katoh, S; Tatlock, JH; Showalter, RE; Villafranca, JE Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands Bioorg Med Chem Lett6:385-390 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM50288764 |
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n/a |
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Name | BDBM50288764 |
Synonyms: | (1S,9R)-13-[2-((1S,2R,5R)-1-Hydroxy-5-isopropyl-2-methyl-cyclohexyl)-2-oxo-acetyl]-3,7-dioxa-13-aza-bicyclo[7.3.1]tridecane-2,8-dione | CHEMBL129672 |
Type | Small organic molecule |
Emp. Form. | C22H33NO7 |
Mol. Mass. | 423.4999 |
SMILES | CC(C)[C@@H]1CC[C@@H](C)[C@@](O)(C1)C(=O)C(=O)N1[C@@H]2CCC[C@H]1C(=O)OCCCOC2=O |
Structure |
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