| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Squalene synthase |
|---|
| Ligand | BDBM50288819 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_201961 |
|---|
| IC50 | 2.5±n/a nM |
|---|
| Citation |  Iwasawa, Y; Shibata, J; Mitsuya, M; Masaki, H; Hayashi, M; Kanno, T; Sawasaki, Y; Hisaka, A; Kamei, T; Tomimoto, K J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs Bioorg Med Chem Lett6:463-466 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Squalene synthase |
|---|
| Name: | Squalene synthase |
|---|
| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48114.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1352847 |
|---|
| Residue: | 417 |
|---|
| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
|
|
|
|---|
| BDBM50288819 |
|---|
| n/a |
|---|
| Name | BDBM50288819 |
|---|
| Synonyms: | (R)-4-[(E)-(1S,2S)-2-(3,4-Dichloro-benzyl)-1-methyl-4-naphthalen-2-yl-but-3-enylcarbamoyl]-3-methyl-butyric acid | CHEMBL143820 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29Cl2NO3 |
|---|
| Mol. Mass. | 498.441 |
|---|
| SMILES | C[C@@H](CC(O)=O)CC(=O)N[C@@H](C)[C@@H](Cc1ccc(Cl)c(Cl)c1)\C=C\c1ccc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
