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Target3-oxo-5-alpha-steroid 4-dehydrogenase 2
LigandBDBM50025356
Substrate/Competitorn/a
Meas. Tech.ChEMBL_202906 (CHEMBL807657)
IC50 4.2±n/a nM
Citation Abell, ADBrandt, MLevy, MAHolt, DA A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme Bioorg Med Chem Lett6:481-484 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Name:3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:Enzyme
Mol. Mass.:28406.59
Organism:Homo sapiens (Human)
Description:P31213
Residue:254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
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  Blast E-value cutoff:
BDBM50025356
n/a
NameBDBM50025356
Synonyms:4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid tert-butylamide | CHEMBL710 | Finasteride | N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
TypeSmall organic molecule
Emp. Form.C23H36N2O2
Mol. Mass.372.5441
SMILESCC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C |c:18|
Structure
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