Reaction Details | |||
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Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | ||
Ligand | BDBM50039285 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_202904 | ||
Ki | 820±n/a nM | ||
Citation | Abell, AD; Brandt, M; Levy, MA; Holt, DA A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme Bioorg Med Chem Lett6:481-484 (1996) Article | ||
More Info.: | Get all data from this article, Assay Method | ||
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | |||
Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | ||
Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 29472.80 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P18405 | ||
Residue: | 259 | ||
Sequence: |
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BDBM50039285 | |||
n/a | |||
Name | BDBM50039285 | ||
Synonyms: | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid tert-butylamide | 9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid tert-butylamide | CHEMBL76192 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H36N2O2 | ||
Mol. Mass. | 372.5441 | ||
SMILES | CC(C)(C)NC(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C |t:13| | ||
Structure |