| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM50288962 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_64369 |
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| IC50 | 7700±n/a nM |
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| Citation |  Kukkola, PJ; Bilci, NA; Kozak, WX; Savage, P; Jeng, AY Optimization of retro-thiorphan for inhibition of endothelin converting enzyme Bioorg Med Chem Lett6:619-624 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 87155.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42892 |
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| Residue: | 770 |
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| Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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| BDBM50288962 |
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| n/a |
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| Name | BDBM50288962 |
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| Synonyms: | CHEMBL156964 | N-[(R)-2-(1H-Indol-3-yl)-1-mercaptomethyl-ethyl]-2-[4-(pyridin-3-ylmethoxy)-phenyl]-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N3O2S |
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| Mol. Mass. | 431.55 |
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| SMILES | SC[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc(OCc2cccnc2)cc1 |
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| Structure | 
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