| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interstitial collagenase |
|---|
| Ligand | BDBM50289126 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_101764 |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Chapman, KT; Durette, PL; Caldwell, CG; Sperow, KM; Niedzwiecki, LM; Harrison, RK; Saphos, C; Christen, AJ; Olszewski, JM; Moore, VL; MacCoss, M; Hagmann, WK Orally active inhibitors of stromelysin-1 (MMP-3) Bioorg Med Chem Lett6:803-806 (1996) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interstitial collagenase |
|---|
| Name: | Interstitial collagenase |
|---|
| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54010.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03956 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
|---|
| BDBM50289126 |
|---|
| n/a |
|---|
| Name | BDBM50289126 |
|---|
| Synonyms: | (R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-6-(4-propyl-phenyl)-hexanoic acid | CHEMBL352609 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H38N2O4 |
|---|
| Mol. Mass. | 466.6123 |
|---|
| SMILES | CCCc1ccc(CC[C@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)Nc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
