| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50175518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_144622 |
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| Ki | 0.070000±n/a nM |
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| Citation |  Warshawsky, AM; Flynn, GA; Koehl, JR; Mehdi, S; Vaz, RJ The synthesis of aminobenzazepinones as anti-phenylalanine dipeptide mimics and their use in nep inhibition Bioorg Med Chem Lett6:957-962 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
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| Type: | Protein |
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| Mol. Mass.: | 85789.59 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07861 |
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| Residue: | 750 |
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| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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| BDBM50175518 |
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| n/a |
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| Name | BDBM50175518 |
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| Synonyms: | (3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid | CHEMBL198316 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O4S |
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| Mol. Mass. | 438.539 |
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| SMILES | OC(=O)[C@H]1CCCC2N1C(=O)[C@H](Cc1ccccc21)NC(=O)[C@H](S)Cc1ccccc1 |
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| Structure | 
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